Jobs in San Francisco, CA

Menlo Ventures Portfolio

Full-time · San Francisco, CA · $190,000 – $230,000

This role owns the commercial side of Anthropic's R&D vendor portfolio, negotiating contracts, managing pricing, and driving vendor performance for critical services like human data operations. It suits someone with deep strategic sourcing experience in services categories who can operate at pace, lead major negotiations independently, and bring analytical rigor to cost and contract structures.

Listed on Menlo Ventures Portfolio’s careers site · Apply there ↗

Astranis

San Francisco, CA · $29 / hour

Listed on Astranis’s careers site · Apply there ↗

Crusoe

San Francisco, CA · $170,000 – $205,000

A senior backend engineer role building the foundational cloud platform services that support Crusoe's AI infrastructure business. You'll own critical systems like the API gateway, quota management, and customer notifications while working on scaling and reliability as the customer base grows.

Listed on Crusoe’s careers site · Apply there ↗

Menlo Ventures Portfolio

Full-time · San Francisco, CA · $320,000 – $405,000

This role builds an AI-powered CI/CD pipeline for Anthropic's GTM systems, where agents, humans, and AI assistants collaborate in a release process. It suits DevOps engineers who've operated production platforms, understand Salesforce deployments, and have thoughtful opinions about where automation belongs versus human oversight.

Listed on Menlo Ventures Portfolio’s careers site · Apply there ↗

Astranis

San Francisco, CA · $29 / hour

Listed on Astranis’s careers site · Apply there ↗

Crusoe

Full-time · San Francisco, CA · $215,000 – $260,000

Crusoe Cloud is seeking a Staff Software Engineer to lead the development of their Software Defined Networking infrastructure, focusing on kernel-level optimization and high-performance packet processing. This role suits experienced systems engineers who have built production networking systems and want to architect next-generation cloud networking at scale.

Listed on Crusoe’s careers site · Apply there ↗

Menlo Ventures Portfolio

San Francisco, CA · $290,000 – $365,000 · Remote

Listed on Menlo Ventures Portfolio’s careers site · Apply there ↗

Astranis

San Francisco, CA · $29 / hour

Listed on Astranis’s careers site · Apply there ↗

Crusoe

San Francisco, CA · $215,000 – $260,000

Crusoe is seeking a Staff Product Manager to own the storage product roadmap for their AI infrastructure platform, managing block, file, and object storage solutions that support demanding machine learning workloads. This role combines customer discovery, technical strategy, and cross-functional leadership to shape how the company's storage offering competes in the rapidly growing AI compute market.

Listed on Crusoe’s careers site · Apply there ↗

Menlo Ventures Portfolio

San Francisco, CA · $200,000 – $320,000

This role leads customer success for one of Anthropic's largest enterprise clients, serving as their strategic advisor on AI adoption across Claude's API, Code, and other products. It suits someone with deep enterprise experience who can drive organization-wide adoption programs, understand technical AI concepts, and build trust with C-suite stakeholders.

Listed on Menlo Ventures Portfolio’s careers site · Apply there ↗

Astranis

San Francisco, CA · $29 / hour

Listed on Astranis’s careers site · Apply there ↗

Crusoe

San Francisco, CA

Listed on Crusoe’s careers site · Apply there ↗

Menlo Ventures Portfolio

Full-time · San Francisco, CA · $285,000 – $325,000

This role leads Anthropic's global corporate network infrastructure across offices and research facilities, balancing production-grade reliability with pragmatic engineering judgment. It's for an experienced network leader who combines deep technical expertise in campus and edge systems with people management, comfortable owning decisions from wiring closets to executive defense.

Listed on Menlo Ventures Portfolio’s careers site · Apply there ↗

Astranis

San Francisco, CA

Listed on Astranis’s careers site · Apply there ↗

Crusoe

Full-time · San Francisco, CA · $285,000 – $335,000

Principal Product Manager role overseeing the long-term architecture and vendor strategy for Crusoe's storage infrastructure that supports massive AI workloads. This is for someone with deep storage expertise and infrastructure leadership experience who can set multi-year technical direction alongside senior engineers.

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Menlo Ventures Portfolio

Full-time · San Francisco, CA · $300,000 – $320,000

Anthropic seeks a medicinal chemist to lead hands-on synthesis and characterization work for their life sciences research group, designing and testing small molecules informed by AI. You'll bridge computational predictions and wet-lab validation, working across chemistry, AI research, and external partners to accelerate drug discovery.

Listed on Menlo Ventures Portfolio’s careers site · Apply there ↗

Astranis

San Francisco, CA

Listed on Astranis’s careers site · Apply there ↗

Crusoe

San Francisco, CA · $225,000 – $255,000

Crusoe seeks a Principal Enterprise Technology Architect to design and govern the unified technical vision for its business systems — currently running as separate platforms for finance, operations, and people. You'd own the greenfield architecture work to integrate these systems, define master data models, and establish governance standards, working as a senior individual contributor who influences through expertise rather than direct authority.

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Menlo Ventures Portfolio

Full-time · San Francisco, CA · $215,000 – $300,000

Build and run AI-powered workflows that automate partner operations at an AI safety company, turning manual processes into Claude-powered automations that handle application triage, onboarding, and partner communications. This role suits engineers who enjoy shipping working code quickly, designing systems that balance automation with human oversight, and collaborating closely with non-technical teams to find and solve their highest-friction problems.

Listed on Menlo Ventures Portfolio’s careers site · Apply there ↗

Astranis

San Francisco, CA · $29 / hour

Listed on Astranis’s careers site · Apply there ↗

Crusoe

San Francisco, CA · $285,000 – $335,000

Lead infrastructure security strategy and organizational growth at a GPU cloud provider building AI compute infrastructure. This role suits executives with deep cloud security experience who can architect security platforms, mentor engineering leaders, and align technical strategy with business objectives at hyperscale.

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Menlo Ventures Portfolio

Full-time · San Francisco, CA · $205,000 – $270,000

This role builds and maintains financial planning platforms like Pigment and Anaplan, connecting them to data warehouses and ERP systems to support forecasting and reporting. It suits engineers with FP&A domain expertise who can write production code, manage system operations, and work across finance and technical teams.

Listed on Menlo Ventures Portfolio’s careers site · Apply there ↗

Astranis

San Francisco, CA · $29 / hour

Listed on Astranis’s careers site · Apply there ↗

Crusoe

Full-time · San Francisco, CA · $175,000 – $200,000

This role supports enterprise customers deploying AI inference workloads on Crusoe's infrastructure platform, bridging technical and business needs while helping optimize model serving and GPU utilization. It suits someone with cloud platform experience and a solid understanding of AI/ML technologies who enjoys hands-on customer engagement and cross-team coordination.

Listed on Crusoe’s careers site · Apply there ↗

Menlo Ventures Portfolio

San Francisco, CA · $240,000 – $325,000

Listed on Menlo Ventures Portfolio’s careers site · Apply there ↗