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Merck

Principal Scientist, Lab Platform Disruptive Technologies

Merck

Cambridge, MA · full time · Principal

$194,100 – $305,600

Listed on Merck’s own careers site. You apply with them directly — we never stand between you and the employer.

What this role is

Lead the development and deployment of next-generation experimental technologies for biologics discovery, translating emerging methods into scalable internal capabilities that accelerate drug programs through high-throughput quantitative data generation. This role suits an experienced scientist with deep expertise in assay development and lab-based methods who can bridge hands-on technical work with team leadership and cross-functional collaboration.

Our summary, not Merck’s wording. The full posting is on their site.

Skills this role names

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What they ask for

Required

  • PhD in Biochemistry, Bioengineering, Chemical Biology or related field with 7+ years industry experience (or MS/BS with 12+ years)
  • Experience developing large-scale, high-throughput quantitative experimental methods for biologics discovery
  • Track record of translating published or externally developed methods into demonstrable internal value
  • Leadership and team management experience
  • Deep hands-on expertise in quantitative pooled binding assays, high-throughput endpoint assays, lab-on-chip, or microfluidics
  • Strong biochemistry and biophysical characterization knowledge
  • Cross-functional project leadership experience
  • Ability to collaborate across reporting lines with protein engineers and data scientists

Nice to have

  • Understanding of protein structure-function relationships
  • Experience with in vitro transcription and translation
  • Background in biophysical protein characterization
  • Therapeutic high-throughput developability assessment
  • Automation and scalable experimental workflow design
  • Experience with generative AI and machine learning workflows

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