# Senior Principal Scientist, Pharmacokinetics

Hiring organization: [Merck](https://career.thegoodapps.co/organizations/merck)

Canonical page: https://career.thegoodapps.co/jobs/e4a016ab-44d1-47ff-8d4f-2e72c62bd86e

Listed on Merck's own careers site. Applications go to them directly.

- Employment type: full time
- Seniority: Lead / Staff / Principal
- Location: South San Francisco, CA
- Salary: 194100 – 305600 USD per year

## Summary

This role leads drug metabolism and pharmacokinetics (DMPK) strategy for an established pharma company's conjugate and novel modality programs, requiring someone with 12+ years of deep expertise in translational pharmacology and the ability to manage scientific teams across discovery and development.

_Our summary, not Merck's wording._

## Skills named

People Management, Pharmacology, Portfolio Management

## Required

- Master's degree with 15+ years or Ph.D. with 12+ years in pharmacokinetics, drug metabolism, pharmaceutical sciences, or related discipline
- Extensive experience in DMPK, ADME, pharmacokinetics, and translational science with demonstrated scientific impact
- Deep expertise in ADME, PK, PK/PD, bioanalysis, and translational interpretation applied to drug conjugates or biologics
- Ability to design, interpret, and integrate in vitro and in vivo data for program progression and regulatory strategy
- Experience as DMPK representative on cross-functional teams influencing program strategy
- Understanding of nonclinical-to-clinical translation and IND-enabling requirements
- Excellent written and verbal communication skills for technical and senior audiences
- Strong collaboration, mentoring, and talent development capabilities
- Direct management of a team of principal investigators and scientific experts

## Nice to have

- Track record of scientific leadership shaping strategy and driving decisions in portfolio environments
- Experience with small molecule ADME drug discovery applicable to conjugates
- Familiarity with model-informed drug discovery approaches including PBPK, population PK, or exposure-response
- Demonstrated external scientific visibility through publications, presentations, or consortia participation

Apply on Merck's site: https://msd.wd5.myworkdayjobs.com/en-US/SearchJobs/job/USA---California---South-San-Francisco-Grand-Ave/Senior-Principal-Scientist--Pharmacokinetics_R410391-1