# Senior Director, Advanced Pharmacometrics, Quantitative Pharmacology and Pharmacometrics – Immuno-Oncology (Hybrid or Remote)

Hiring organization: [Merck](https://career.thegoodapps.co/organizations/merck)

Canonical page: https://career.thegoodapps.co/jobs/8182b10f-8f1f-4838-a4ac-46235591398c

Listed on Merck's own careers site. Applications go to them directly.

- Employment type: full time
- Seniority: Senior
- Remote: yes
- Salary: 210400 – 331100 USD per year

## Summary

This role leads advanced pharmacometrics strategy for an immuno-oncology portfolio, overseeing the development of sophisticated mathematical models to inform clinical trial design and regulatory decisions. It suits accomplished scientists with deep expertise in oncology drug development, quantitative pharmacology, and proven ability to influence strategy across a large, matrixed organization.

_Our summary, not Merck's wording._

## Skills named

Artificial Intelligence, Data Modeling, Machine Learning, R

## Required

- Ph.D. in pharmacokinetics, pharmacodynamics, pharmacometrics, mathematics, statistics, biostatistics, chemical engineering, biomedical engineering, or related discipline with 10+ years pharmaceutical drug development experience including substantial pharmacometrics roles, OR Master's/PharmD with 15+ years pharmaceutical drug development with demonstrated increasing responsibility and leadership
- Extensive experience applying model-informed drug development in oncology
- Proficiency in advanced pharmacometrics methods including Bayesian hierarchical models, joint tumor and survival models, dropout models, model-based meta-analysis, and clinical trial simulation
- Hands-on experience with NONMEM, Pumas, Stan, R, or other Bayesian platforms
- Understanding of oncology biology, translational pathways, and clinical endpoints such as ORR, PFS, OS
- Demonstrated impact across multiple therapeutic modalities including ADCs, TCEs, mAbs, cytokines, and small molecules
- Excellent written and verbal communication with track record of cross-functional collaboration and senior-level influence in matrixed environments

## Nice to have

- Experience integrating AI/ML methods into clinical pharmacology and pharmacometrics workflows
- Experience with population PK/PD modeling across multiple therapeutic areas

Apply on Merck's site: https://msd.wd5.myworkdayjobs.com/en-US/SearchJobs/job/USA---New-Jersey---Rahway/Senior-Director--Advanced-Pharmacometrics--Quantitative-Pharmacology-and-Pharmacometrics---Immuno-Oncology--Hybrid-or-Remote-_R408271-1