# Sr. Director, Head, Quantitative Systems Pharmacology

Hiring organization: [Moderna](https://career.thegoodapps.co/organizations/moderna)

Canonical page: https://career.thegoodapps.co/jobs/54369b43-f844-4a93-b502-dfc6e5336678

Listed on Moderna's own careers site. Applications go to them directly.

- Seniority: Director
- Salary: 196700 – 353400 USD per year

## Summary

Lead the quantitative systems pharmacology function at a major mRNA therapeutics company, defining how mechanistic modeling and model-informed drug development drive early-stage decisions across oncology and immunotherapy programs. This role suits a seasoned quantitative scientist with deep expertise in translational pharmacology and the ability to influence strategy across discovery, preclinical, and clinical teams.

_Our summary, not Moderna's wording._

## Skills named

MATLAB, Python, R

## Required

- Ph.D. in systems pharmacology, bioengineering, applied mathematics, pharmacology, or related quantitative discipline (or MS with 20+ years experience)
- 10+ years industry experience in QSP or mechanistic modeling
- At least 7 years supporting oncology drug development
- Deep immuno-oncology expertise
- Proven track record applying mechanistic and translational models from preclinical through clinical stages
- Deep understanding of PK/PD, systems biology, disease pathway modeling, and biomarker integration
- Demonstrated scientific leadership and mentoring of quantitative scientists
- Proficiency in modeling platforms such as MATLAB/SimBiology, Monolix, R, or Python
- Strong communication skills translating quantitative findings for multidisciplinary audiences
- Ability to operate strategically while remaining hands-on in modeling
- Experience contributing to regulatory filings and Health Authority interactions with model-informed approaches

## Nice to have

- Experience with T cell engagers, adoptive cell therapy, or cancer immunotherapy approaches
- Experience in mRNA or novel therapeutic modalities like gene therapy or biologics
- Familiarity with PBPK modeling, virtual populations, or digital-twin simulation
- Experience building infrastructure or toolchains for scalable modeling and data integration
- Track record of scientific publications and external visibility

Apply on Moderna's site: https://modernatx.wd1.myworkdayjobs.com/en-US/M_tx/job/Cambridge-Massachusetts/Sr-Director--Head--Quantitative-Systems-Pharmacology_R19268