# Principal Scientist, Protein Design

Hiring organization: [Moderna](https://career.thegoodapps.co/organizations/moderna)

Canonical page: https://career.thegoodapps.co/jobs/3f47b0c9-6b5f-4eea-8f7c-0700232f494d

Listed on Moderna's own careers site. Applications go to them directly.

- Employment type: full time
- Seniority: Principal
- Salary: 142500 – 256500 USD per year

## Summary

Lead the design and execution of high-throughput mammalian cell-surface screening campaigns to optimize viral and bacterial antigens for mRNA vaccines, partnering with computational protein design teams to drive candidates from discovery to the clinic. This role suits a scientist with deep expertise in in vitro selection and directed evolution who is ready to own a core discovery capability and mentor junior researchers.

_Our summary, not Moderna's wording._

## Required

- PhD in Immunology, Molecular Biology, Biochemistry, Protein Engineering, or related field
- 5+ years post-PhD experience leading in vitro selection or mammalian cell-surface display
- Demonstrated ability to drive complex screening campaigns end-to-end
- Deep expertise in mammalian display systems and high-throughput selection strategies
- Strong working knowledge of computational, structure-based, or AI-driven protein design workflows
- Scientific independence and ownership consistent with Principal Scientist role

## Nice to have

- Expertise with glycoprotein antigen expression and engineering including folding, trafficking, cleavage, stability, and glycan impacts
- Strong capabilities in library design and construction including site-saturation, combinatorial, error-prone approaches, and DNA assembly
- Experience with NGS-based readouts and quantitative enrichment analysis

Apply on Moderna's site: https://modernatx.wd1.myworkdayjobs.com/en-US/M_tx/job/Cambridge-Massachusetts/Principal-Scientist--Protein-Design_R18853-2